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Clinical and radiographic outcome of a treat-to-target strategy using methotrexate and intra-articular glucocorticoids with or without adalimumab induction: a 2-year investigator-initiated, double-blinded, randomised, controlled trial (OPERA).

Identifieur interne : 000219 ( Main/Exploration ); précédent : 000218; suivant : 000220

Clinical and radiographic outcome of a treat-to-target strategy using methotrexate and intra-articular glucocorticoids with or without adalimumab induction: a 2-year investigator-initiated, double-blinded, randomised, controlled trial (OPERA).

Auteurs : K. H Rslev-Petersen [Danemark] ; M L Hetland [Danemark] ; L M Rnbjerg [Danemark] ; P. Junker [Danemark] ; J. P Denphant [Danemark] ; T. Ellingsen [Danemark] ; P. Ahlquist [Danemark] ; H. Lindegaard [Danemark] ; A. Linauskas [Danemark] ; A. Schlemmer [Danemark] ; M Y Dam [Danemark] ; I. Hansen [Danemark] ; T. Lottenburger [Danemark] ; C G Ammitzb Ll [Danemark] ; A. J Rgensen [Danemark] ; S B Krintel [Danemark] ; J. Raun [Danemark] ; J S Johansen [Danemark] ; M. Stergaard [Danemark] ; K. Stengaard-Pedersen [Danemark]

Source :

RBID : pubmed:26489704

Abstract

To study clinical and radiographic outcomes after withdrawing 1 year's adalimumab induction therapy for early rheumatoid arthritis (eRA) added to a methotrexate and intra-articular triamcinolone hexacetonide treat-to-target strategy (NCT00660647).

DOI: 10.1136/annrheumdis-2015-208166
PubMed: 26489704


Affiliations:


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Le document en format XML

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<nlm:affiliation>Department of Rheumatology, Vendsyssel Hospital, Hjørring, Denmark.</nlm:affiliation>
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<name sortKey="Ammitzb Ll, C G" sort="Ammitzb Ll, C G" uniqKey="Ammitzb Ll C" first="C G" last="Ammitzb Ll">C G Ammitzb Ll</name>
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<nlm:affiliation>Aarhus Hospital NBG, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation>
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<nlm:affiliation>Aarhus Hospital NBG, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation>
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<name sortKey="Krintel, S B" sort="Krintel, S B" uniqKey="Krintel S" first="S B" last="Krintel">S B Krintel</name>
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<nlm:affiliation>Department of Rheumatology, Copenhagen University Hospital Glostrup, Glostrup, Denmark Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Copenhagen University Hospital Glostrup, Glostrup, Denmark Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup</wicri:regionArea>
<wicri:noRegion>Glostrup</wicri:noRegion>
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<author>
<name sortKey="Raun, J" sort="Raun, J" uniqKey="Raun J" first="J" last="Raun">J. Raun</name>
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<nlm:affiliation>Department of Rheumatology, King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark Institute of Health Research, University of Southern Denmark, Gråsten, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark Institute of Health Research, University of Southern Denmark, Gråsten</wicri:regionArea>
<wicri:noRegion>Gråsten</wicri:noRegion>
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<name sortKey="Johansen, J S" sort="Johansen, J S" uniqKey="Johansen J" first="J S" last="Johansen">J S Johansen</name>
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<nlm:affiliation>Departments of Medicine and Oncology, Copenhagen University Hospital at Herlev, Herlev, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Departments of Medicine and Oncology, Copenhagen University Hospital at Herlev, Herlev</wicri:regionArea>
<wicri:noRegion>Herlev</wicri:noRegion>
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<name sortKey=" Stergaard, M" sort=" Stergaard, M" uniqKey=" Stergaard M" first="M" last=" Stergaard">M. Stergaard</name>
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<nlm:affiliation>Department of Rheumatology, Copenhagen University Hospital Glostrup, Glostrup, Denmark Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Copenhagen University Hospital Glostrup, Glostrup, Denmark Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup</wicri:regionArea>
<wicri:noRegion>Glostrup</wicri:noRegion>
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<name sortKey="Stengaard Pedersen, K" sort="Stengaard Pedersen, K" uniqKey="Stengaard Pedersen K" first="K" last="Stengaard-Pedersen">K. Stengaard-Pedersen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Aarhus Hospital NBG, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Aarhus Hospital NBG, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
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<title xml:lang="en">Clinical and radiographic outcome of a treat-to-target strategy using methotrexate and intra-articular glucocorticoids with or without adalimumab induction: a 2-year investigator-initiated, double-blinded, randomised, controlled trial (OPERA).</title>
<author>
<name sortKey="H Rslev Petersen, K" sort="H Rslev Petersen, K" uniqKey="H Rslev Petersen K" first="K" last="H Rslev-Petersen">K. H Rslev-Petersen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark Institute of Health Research, University of Southern Denmark, Gråsten, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark Institute of Health Research, University of Southern Denmark, Gråsten</wicri:regionArea>
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</affiliation>
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<name sortKey="Hetland, M L" sort="Hetland, M L" uniqKey="Hetland M" first="M L" last="Hetland">M L Hetland</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, Copenhagen University Hospital Glostrup, Glostrup, Denmark Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Copenhagen University Hospital Glostrup, Glostrup, Denmark Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup</wicri:regionArea>
<wicri:noRegion>Glostrup</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey=" Rnbjerg, L M" sort=" Rnbjerg, L M" uniqKey=" Rnbjerg L" first="L M" last=" Rnbjerg">L M Rnbjerg</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, Copenhagen University Hospital Glostrup, Glostrup, Denmark Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Copenhagen University Hospital Glostrup, Glostrup, Denmark Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup</wicri:regionArea>
<wicri:noRegion>Glostrup</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Junker, P" sort="Junker, P" uniqKey="Junker P" first="P" last="Junker">P. Junker</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, Odense University Hospital, Odense, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Odense University Hospital, Odense</wicri:regionArea>
<wicri:noRegion>Odense</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="P Denphant, J" sort="P Denphant, J" uniqKey="P Denphant J" first="J" last="P Denphant">J. P Denphant</name>
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<nlm:affiliation>Department of Rheumatology, Copenhagen University Hospital at Gentofte, Gentofte, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Copenhagen University Hospital at Gentofte, Gentofte</wicri:regionArea>
<wicri:noRegion>Gentofte</wicri:noRegion>
</affiliation>
</author>
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<name sortKey="Ellingsen, T" sort="Ellingsen, T" uniqKey="Ellingsen T" first="T" last="Ellingsen">T. Ellingsen</name>
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<nlm:affiliation>Department of Rheumatology, Odense University Hospital, Odense, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Odense University Hospital, Odense</wicri:regionArea>
<wicri:noRegion>Odense</wicri:noRegion>
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</author>
<author>
<name sortKey="Ahlquist, P" sort="Ahlquist, P" uniqKey="Ahlquist P" first="P" last="Ahlquist">P. Ahlquist</name>
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<nlm:affiliation>Department of Medicine, Vejle Regional Hospital, Vejle, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Medicine, Vejle Regional Hospital, Vejle</wicri:regionArea>
<wicri:noRegion>Vejle</wicri:noRegion>
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</author>
<author>
<name sortKey="Lindegaard, H" sort="Lindegaard, H" uniqKey="Lindegaard H" first="H" last="Lindegaard">H. Lindegaard</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, Odense University Hospital, Odense, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Odense University Hospital, Odense</wicri:regionArea>
<wicri:noRegion>Odense</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Linauskas, A" sort="Linauskas, A" uniqKey="Linauskas A" first="A" last="Linauskas">A. Linauskas</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, Vendsyssel Hospital, Hjørring, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Vendsyssel Hospital, Hjørring</wicri:regionArea>
<wicri:noRegion>Hjørring</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Schlemmer, A" sort="Schlemmer, A" uniqKey="Schlemmer A" first="A" last="Schlemmer">A. Schlemmer</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, Aalborg Hospital, Aalborg, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Aalborg Hospital, Aalborg</wicri:regionArea>
<wicri:noRegion>Aalborg</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Dam, M Y" sort="Dam, M Y" uniqKey="Dam M" first="M Y" last="Dam">M Y Dam</name>
<affiliation wicri:level="1">
<nlm:affiliation>Diagnostic Centre, Silkeborg Region Hospital, Silkeborg, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Diagnostic Centre, Silkeborg Region Hospital, Silkeborg</wicri:regionArea>
<wicri:noRegion>Silkeborg</wicri:noRegion>
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</author>
<author>
<name sortKey="Hansen, I" sort="Hansen, I" uniqKey="Hansen I" first="I" last="Hansen">I. Hansen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, Viborg Regional Hospital, Viborg, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Viborg Regional Hospital, Viborg</wicri:regionArea>
<wicri:noRegion>Viborg</wicri:noRegion>
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</author>
<author>
<name sortKey="Lottenburger, T" sort="Lottenburger, T" uniqKey="Lottenburger T" first="T" last="Lottenburger">T. Lottenburger</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, Vendsyssel Hospital, Hjørring, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Vendsyssel Hospital, Hjørring</wicri:regionArea>
<wicri:noRegion>Hjørring</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ammitzb Ll, C G" sort="Ammitzb Ll, C G" uniqKey="Ammitzb Ll C" first="C G" last="Ammitzb Ll">C G Ammitzb Ll</name>
<affiliation wicri:level="1">
<nlm:affiliation>Aarhus Hospital NBG, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Aarhus Hospital NBG, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="J Rgensen, A" sort="J Rgensen, A" uniqKey="J Rgensen A" first="A" last="J Rgensen">A. J Rgensen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Aarhus Hospital NBG, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Aarhus Hospital NBG, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Krintel, S B" sort="Krintel, S B" uniqKey="Krintel S" first="S B" last="Krintel">S B Krintel</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, Copenhagen University Hospital Glostrup, Glostrup, Denmark Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Copenhagen University Hospital Glostrup, Glostrup, Denmark Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup</wicri:regionArea>
<wicri:noRegion>Glostrup</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Raun, J" sort="Raun, J" uniqKey="Raun J" first="J" last="Raun">J. Raun</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark Institute of Health Research, University of Southern Denmark, Gråsten, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark Institute of Health Research, University of Southern Denmark, Gråsten</wicri:regionArea>
<wicri:noRegion>Gråsten</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Johansen, J S" sort="Johansen, J S" uniqKey="Johansen J" first="J S" last="Johansen">J S Johansen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Departments of Medicine and Oncology, Copenhagen University Hospital at Herlev, Herlev, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Departments of Medicine and Oncology, Copenhagen University Hospital at Herlev, Herlev</wicri:regionArea>
<wicri:noRegion>Herlev</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey=" Stergaard, M" sort=" Stergaard, M" uniqKey=" Stergaard M" first="M" last=" Stergaard">M. Stergaard</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, Copenhagen University Hospital Glostrup, Glostrup, Denmark Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Copenhagen University Hospital Glostrup, Glostrup, Denmark Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup</wicri:regionArea>
<wicri:noRegion>Glostrup</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Stengaard Pedersen, K" sort="Stengaard Pedersen, K" uniqKey="Stengaard Pedersen K" first="K" last="Stengaard-Pedersen">K. Stengaard-Pedersen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Aarhus Hospital NBG, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Aarhus Hospital NBG, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Annals of the rheumatic diseases</title>
<idno type="e-ISSN">1468-2060</idno>
<imprint>
<date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">To study clinical and radiographic outcomes after withdrawing 1 year's adalimumab induction therapy for early rheumatoid arthritis (eRA) added to a methotrexate and intra-articular triamcinolone hexacetonide treat-to-target strategy (NCT00660647).</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Danemark</li>
</country>
</list>
<tree>
<country name="Danemark">
<noRegion>
<name sortKey="H Rslev Petersen, K" sort="H Rslev Petersen, K" uniqKey="H Rslev Petersen K" first="K" last="H Rslev-Petersen">K. H Rslev-Petersen</name>
</noRegion>
<name sortKey=" Rnbjerg, L M" sort=" Rnbjerg, L M" uniqKey=" Rnbjerg L" first="L M" last=" Rnbjerg">L M Rnbjerg</name>
<name sortKey=" Stergaard, M" sort=" Stergaard, M" uniqKey=" Stergaard M" first="M" last=" Stergaard">M. Stergaard</name>
<name sortKey="Ahlquist, P" sort="Ahlquist, P" uniqKey="Ahlquist P" first="P" last="Ahlquist">P. Ahlquist</name>
<name sortKey="Ammitzb Ll, C G" sort="Ammitzb Ll, C G" uniqKey="Ammitzb Ll C" first="C G" last="Ammitzb Ll">C G Ammitzb Ll</name>
<name sortKey="Dam, M Y" sort="Dam, M Y" uniqKey="Dam M" first="M Y" last="Dam">M Y Dam</name>
<name sortKey="Ellingsen, T" sort="Ellingsen, T" uniqKey="Ellingsen T" first="T" last="Ellingsen">T. Ellingsen</name>
<name sortKey="Hansen, I" sort="Hansen, I" uniqKey="Hansen I" first="I" last="Hansen">I. Hansen</name>
<name sortKey="Hetland, M L" sort="Hetland, M L" uniqKey="Hetland M" first="M L" last="Hetland">M L Hetland</name>
<name sortKey="J Rgensen, A" sort="J Rgensen, A" uniqKey="J Rgensen A" first="A" last="J Rgensen">A. J Rgensen</name>
<name sortKey="Johansen, J S" sort="Johansen, J S" uniqKey="Johansen J" first="J S" last="Johansen">J S Johansen</name>
<name sortKey="Junker, P" sort="Junker, P" uniqKey="Junker P" first="P" last="Junker">P. Junker</name>
<name sortKey="Krintel, S B" sort="Krintel, S B" uniqKey="Krintel S" first="S B" last="Krintel">S B Krintel</name>
<name sortKey="Linauskas, A" sort="Linauskas, A" uniqKey="Linauskas A" first="A" last="Linauskas">A. Linauskas</name>
<name sortKey="Lindegaard, H" sort="Lindegaard, H" uniqKey="Lindegaard H" first="H" last="Lindegaard">H. Lindegaard</name>
<name sortKey="Lottenburger, T" sort="Lottenburger, T" uniqKey="Lottenburger T" first="T" last="Lottenburger">T. Lottenburger</name>
<name sortKey="P Denphant, J" sort="P Denphant, J" uniqKey="P Denphant J" first="J" last="P Denphant">J. P Denphant</name>
<name sortKey="Raun, J" sort="Raun, J" uniqKey="Raun J" first="J" last="Raun">J. Raun</name>
<name sortKey="Schlemmer, A" sort="Schlemmer, A" uniqKey="Schlemmer A" first="A" last="Schlemmer">A. Schlemmer</name>
<name sortKey="Stengaard Pedersen, K" sort="Stengaard Pedersen, K" uniqKey="Stengaard Pedersen K" first="K" last="Stengaard-Pedersen">K. Stengaard-Pedersen</name>
</country>
</tree>
</affiliations>
</record>

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